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Friday, March 2, 2018

ADVIL: My Third Modern Miracle

I published SIMPLE SOLUTIONS for Planet Earth in 2007.  This book drew together all I knew about energy and the environment, topics that dominated my professional career.  

After the relief of completing that manuscript, I thought, why don't I now write a book of things beyond my knowledge.  That was SIMPLE SOLUTIONS for Humanity.

For the chapter on religion, The Golden Evolution, I thought of two modern miracles. I then attempted a scientific explanation of the major miracles.  

Did you know Moses is also known as Moshe, Munius, Yered, Anigdor, Chever, Avi Socho, Yekutiel, Avi Zanoach, Toviah, Shemayah, Ben Evyatar, and Levi?  And he lived to the age of 120.  Anyway, click on the above to mull over the candidate proposals.  In that same posting, the reality of Jesus walking on water and feeding 5,000 with five loaves of barley bread and two tilapia.  I had indicated fish in my book, but just two weeks ago at Aquaculture American 2018 learned that these fish were tilapia

I updated my two modern miracles in this blog site.  One of these miracles defies description.  As a PhD chemical engineer, I am appreciative of how corrosion and wear can dull a blade.  How then can a razor blade last for years?  Since I wrote SIMPLE SOLUTIONS for Humanity a decade ago, I have only used two blades at home.  The second was made necessary around five years ago when I dropped my razor and it cracked.  So I bought a whole new set of Schick.

The other, a soap in a cloth bag safety pinned to the bottom of your bed, and under the sheet, even Snopes, famed for debunking Urban Legends, was stumped.  The best they could up with was some placebo effect.  I've personally thought that the effect was psychosomatic, and, to my almost embarrassment, it does work for me.  Here is a rather complete analysis of this modern miracle from The People's Pharmacy.

There are, too, the not so ancient, and mostly still religious, miracles, such as what happened in Fatima, Portugal in 1917.  The medical field has largely cured smallpox and polio, and is just beginning to work on DNA. The Human Genome Project is a kind of miracle.  Like the miracle of birth, what we can anticipate about things to come will mostly be glorious, but, for example, suppose the aging gene is checked, who determines who gets born?  

Thus, touting Advil as my third modern miracle seems almost inconsequential.  But that is in keeping with what qualifies as MY modern miracle.  It has to be flukey and almost flaky.  This third one, though, as far as I know, only works for me.  No one I know has even tried it to treat the flu, and I don't recommend you do, either, for you need to first check with your personal physician, and be aware of what is Advil.  I might add that while I have not yet had the opportunity to see if Advil will work for the ailment mentioned in the final sentence of this posting (above the RED section), this enrichment topped off what could grow into a true modern miracle.

In Wikipedia, Advil and Motrin are trade names for Ibuprofen, a nonsteroidal anti-inflammatory drug (NAID),  discovered in 1961, and used to treat pain, fever and inflammation.  Aspirin is a NAID, and so is Aleve.  You need to be especially careful if you are pregnant or have asthma, and there is a wide range of adverse effects for anyone, but Ibuprofen is on the World Health Organizations's List of Essential Medicines.  Drinking alcohol can lead to stomach bleeding, but toxic effects should not occur for anyone of average weight if you take less than sixteen 200 mg pills/day.  In any case, the severity should not be lethal.   I've taken exactly five 200 mg tablets, two for my first flu cure three years ago, two for my cold retardation yesterday, and one today.  Cost, 5 cents/dose, but as low as 1 cent in developing countries.  But that's Ibuprofen.  

There is a difference between Ibuprofen, Advil and Motrin.  Ibuprofen is cheaper.  I'm looking at an Amazon site where 100 tablets of Advil can be ordered for $9.98, or, around 10 cents/200 mg pill.  500 tablets of Kirkland Ibuprofen costs $7.73, or less than 1.5 cents/200 mg pill.  Why would anyone pay more?  Me, for one, because it's possible that the effect is in part psychosomatic and the effect might not be the same for the generic.

Wikipedia says:

NSAIDs such as ibuprofen work by inhibiting the cyclooxygenase (COX) enzymes, which convert arachidonic acid to prostaglandin H2(PGH2). PGH2, in turn, is converted by other enzymes to several other prostaglandins (which are mediators of pain, inflammation, and fever) and to thromboxane A2 (which stimulates platelet aggregation, leading to the formation of blood clots).

Got that?  The inventor, Steward Adams of the Boots Group (UK), first tested the drug as treatment for his hangover.  Japan sells Ibuprofen in topical form for adult acne.  In some studies, Ibuprofen showed superior results compared with a placebo in the prevention of Alzheimer's disease, when given in low doses over a long time.  Hmmm.....  Ibuprofen might also delay or prevent Parkinson's Disease, something for which aspirin and other NSAIDs  had no effect.  The more research I do, the more I'm beginning to think that maybe I should be taking Advil more regularly.  And I hate pills.  Apparently, there could be some danger in taking Ibuprofen while using dietary supplements like ginkgo, garlic, ginger, ginseng turmeric, coumarin, tamarind and horse chestnut.  Oh, by the way, Ibuprofen (or Advil or Motrin) does seem to reduce the deleterious effects of hangovers.

Just as I was about to post the above, I got a call indicating that my doctor has prescribed Tamiflu, then a second from his nurse, indicating that I tested positive for the flu, and that I needed to be quarantined until I run out of Tamiflu.  I wonder how many pills are coming?  I actually feel okay, today, but with some serious yellow phlegm which I'm expelling from my body in copious quantities.  I just had a normal lunch in my room.  I don't want to contest my doctor's decision, so I guess my Third Modern Miracle option will need to wait until the next flu.

So I looked up Tamiflu:
  • commonly known as Oseltamivir
  • antiviral medication
  • recommended only for those with high risk complications
  • how it works:  
Oseltamivir is a neuraminidase inhibitor, a competitive inhibitor of influenza's neuraminidase enzyme. The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir prevents new viral particles from being released.[43]
  • use is controversial, and, in fact, there seem to be more cons than pros, but I can imagine why I'm being prescribed on the basis of the next bullet
  • seems to minimize contagion in the household and long-term care facilities
  • side effects of vomiting, diarrhea, headache, trouble sleeping, psychiatric (wonder what this is?) symptoms and seizures
  • approved for medical use in the U.S. in 1999 (generic version approved in 2016 when the Roche patent expired)
  • is on the World Health Organization's List of Essential Medicines
  • a full treatment costs $138.70 (note that Advil is at the 20 cents level)
  • there is a cheaper version called Antiflu from India
  • does not work for H1N1 Swine Flu
  • shikimic acid, avilable as an extract for Chinese star anise, was the starting point, but there is growing manufacturing recombinantly in E. coli
  • Tamiflu is supposed to decrease flu severity about 40%
Tamiflu just arrived and the good news is that I'm paying only $5 for this treatment.  Hope it works.



Cara Membuat NPK Organik Cair said...

what a nice writing style, I liked it

Cara Membuat Pupuk Hidroponik Cair said...

that's good, even I recently trying to make our waste as fertilizer, let's keep our planet safe and clean